HELIOS Klinik Hagen-Ambrock

1: Grigoriadis N, Linnebank M, Alexandri N, Muehl S, Hofbauer GF. Considerations

on long-term immuno- intervention in the treatment of multiple sclerosis: an

expert opinion. Expert Opin Pharmacother. 2016 Sep 3. [Epub ahead of print]

PubMed PMID: 27594523.



2: Killeen T, Easthope CS, Filli L, Linnebank M, Curt A, Bolliger M, Zörner B.

Modulating arm swing symmetry with cognitive load: a window on rhythmic spinal

locomotor networks in humans? J Neurotrauma. 2016 Aug 30. [Epub ahead of print]

PubMed PMID: 27574966.



3: Oikonomidi A, Lewczuk P, Kornhuber J, Smulders Y, Linnebank M, Semmler A, Popp

J. Homocysteine metabolism is associated with cerebrospinal fluid levels of

soluble amyloid precursor protein and amyloid beta. J Neurochem. 2016 Aug 10.

doi: 10.1111/jnc.13766. [Epub ahead of print] PubMed PMID: 27507672.



4: Kana V, Petersen JA, Ikenberg K, Chappaz A, Gerth-Kahlert C, Appenzeller P,

Linnebank M. Teaching NeuroImages: Recurrent oculomotor palsies caused by

neurosarcoidosis. Neurology. 2016 Jul 19;87(3):e31-2. doi:

10.1212/WNL.0000000000002865. PubMed PMID: 27432184.



5: Geisseler O, Pflugshaupt T, Buchmann A, Bezzola L, Reuter K, Schuknecht B,

Weller D, Linnebank M, Brugger P. Random number generation deficits in patients

with multiple sclerosis: Characteristics and neural correlates. Cortex. 2016

Sep;82:237-43. doi: 10.1016/j.cortex.2016.05.007. Epub 2016 May 21. PubMed PMID:




6: Pflugshaupt T, Geisseler O, Nyffeler T, Linnebank M. Cognitive Impairment in

Multiple Sclerosis: Clinical Manifestation, Neuroimaging Correlates, and

Treatment. Semin Neurol. 2016 Apr;36(2):203-11. doi: 10.1055/s-0036-1579696. Epub

2016 Apr 26. PubMed PMID: 27116727.



7: Lublin F, Miller DH, Freedman MS, Cree BA, Wolinsky JS, Weiner H, Lubetzki C,

Hartung HP, Montalban X, Uitdehaag BM, Merschhemke M, Li B, Putzki N, Liu FC,

Häring DA, Kappos L; INFORMS study investigators. Oral fingolimod in primary

progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind,

placebo-controlled trial. Lancet. 2016 Mar 12;387(10023):1075-84. doi:

10.1016/S0140-6736(15)01314-8. Epub 2016 Jan 28. PubMed PMID: 26827074.



8: Zörner B, Filli L, Reuter K, Kapitza S, Lörincz L, Sutter T, Weller D, Farkas

M, Easthope CS, Czaplinski A, Weller M, Linnebank M. Prolonged-release fampridine

in multiple sclerosis: Improved ambulation effected by changes in walking

pattern. Mult Scler. 2016 Jan 13. pii: 1352458515622695. [Epub ahead of print]

PubMed PMID: 26762672.



9: Geisseler O, Pflugshaupt T, Bezzola L, Reuter K, Weller D, Schuknecht B,

Brugger P, Linnebank M. Cortical thinning in the anterior cingulate cortex

predicts multiple sclerosis patients' fluency performance in a lateralised

manner. Neuroimage Clin. 2015 Nov 14;10:89-95. doi: 10.1016/j.nicl.2015.11.008.

eCollection 2016. PubMed PMID: 26759784; PubMed Central PMCID: PMC4683425.



10: Pfender N, Linnebank M, Sommerauer M, Tarnutzer AA. Neurosyphilis presenting

as a new onset lateralized movement disorder. J Clin Neurosci. 2015

Oct;22(10):1682-3. doi: 10.1016/j.jocn.2015.03.038. Epub 2015 Jun 6. PubMed PMID:




11: Ulrich A, Müller D, Linnebank M, Tarnutzer AA. Pitfalls in the diagnostic

evaluation of subacute combined degeneration. BMJ Case Rep. 2015 May 14;2015.

pii: bcr2014208622. doi: 10.1136/bcr-2014-208622. PubMed PMID: 25976195.



12: Pfender N, Jelcic I, Linnebank M, Schwarz U, Martin R. Reactivation of

herpesvirus under fingolimod: A case of severe herpes simplex encephalitis.

Neurology. 2015 Jun 9;84(23):2377-8. doi: 10.1212/WNL.0000000000001659. Epub 2015

May 8. PubMed PMID: 25957334; PubMed Central PMCID: PMC4464745.



13: Semmler A, Heese P, Stoffel-Wagner B, Muschler M, Heberlein A, Bigler L,

Prost JC, Frieling H, Kornhuber J, Banger M, Bleich S, Hillemacher T, Linnebank

M. Alcohol abuse and cigarette smoking are associated with global DNA

hypermethylation: results from the German Investigation on Neurobiology in

Alcoholism (GINA). Alcohol. 2015 Mar;49(2):97-101. doi:

10.1016/j.alcohol.2015.01.004. Epub 2015 Jan 20. PubMed PMID: 25702197.



14: Wolpert F, Baráth K, Brakowski J, Renzel R, Linnebank M, Gantenbein AR.

Funicular myelosis in a butcher: it was the cream cans. Case Rep Neurol Med.

2015;2015:827168. doi: 10.1155/2015/827168. Epub 2015 Jan 28. PubMed PMID:

25694837; PubMed Central PMCID: PMC4324743.



15: Bleich S, Semmler A, Frieling H, Thumfart L, Muschler M, Hillemacher T,

Kornhuber J, Kallweit U, Simon M, Linnebank M. Genetic variants of methionine

metabolism and DNA methylation. Epigenomics. 2014;6(6):585-91. doi:

10.2217/epi.14.54. PubMed PMID: 25531253.



16: Haschemi Nassab M, Rhein M, Heese P, Glahn A, Frieling H, Linnebank M, Bleich

S, Kornhuber J, Heberlein A, Grallert H, Peters A, Rawal R, Strauch K,

Hillemacher T. No association between the ALDH2 promoter polymorphism rs886205,

alcohol dependence, and risky alcohol consumption in a German population.

Psychiatr Genet. 2015 Feb;25(1):41-2. doi: 10.1097/YPG.0000000000000073. PubMed

PMID: 25419637.



17: Wegener S, Linnebank M, Martin R, Valavanis A, Weller M. Clinically isolated

neurosarcoidosis: a recommended diagnostic path. Eur Neurol. 2015;73(1-2):71-7.

doi: 10.1159/000366199. Epub 2014 Nov 12. PubMed PMID: 25401278.



18: Pflugshaupt T, Nösberger M, Gutbrod K, Weber KP, Linnebank M, Brugger P.

Bottom-up Visual Integration in the Medial Parietal Lobe. Cereb Cortex. 2016

Mar;26(3):943-9. doi: 10.1093/cercor/bhu256. Epub 2014 Oct 19. PubMed PMID:




19: Keskitalo S, Farkas M, Hanenberg M, Szodorai A, Kulic L, Semmler A, Weller M,

Nitsch RM, Linnebank M. Reciprocal modulation of Aβ42 aggregation by copper and

homocysteine. Front Aging Neurosci. 2014 Sep 8;6:237. doi:

10.3389/fnagi.2014.00237. eCollection 2014. PubMed PMID: 25249976; PubMed Central

PMCID: PMC4157544.



20: Kunkel S, Linnebank M, Staudacher D, Spirig R. [Supporting the self efficacy

of the patient]. Krankenpfl Soins Infirm. 2014;107(1):30-1. German. PubMed PMID:




21: Valavanis A, Schwarz U, Baumann CR, Weller M, Linnebank M. Amyotrophic

lateral sclerosis after embolization of cerebral arterioveneous malformations. J

Neurol. 2014 Apr;261(4):732-7. doi: 10.1007/s00415-014-7260-8. Epub 2014 Feb 8.

PubMed PMID: 24509642.



22: Haertle M, Kallweit U, Weller M, Linnebank M. The presence of oligoclonal IgG

bands in human CSF during the course of neurological diseases. J Neurol. 2014

Mar;261(3):554-60. doi: 10.1007/s00415-013-7234-2. Epub 2014 Jan 22. PubMed PMID:




23: Ineichen BV, Keskitalo S, Farkas M, Bain N, Kallweit U, Weller M, Klotz L,

Linnebank M. Genetic variants of homocysteine metabolism and multiple sclerosis:

a case-control study. Neurosci Lett. 2014 Mar 6;562:75-8. doi:

10.1016/j.neulet.2014.01.008. Epub 2014 Jan 9. PubMed PMID: 24412677.



24: Kallweit U, Baumann CR, Harzheim M, Hidalgo H, Pöhlau D, Bassetti CL,

Linnebank M, Valko PO. Fatigue and sleep-disordered breathing in multiple

sclerosis: a clinically relevant association? Mult Scler Int. 2013;2013:286581.

doi: 10.1155/2013/286581. Epub 2013 Oct 22. PubMed PMID: 24251039; PubMed Central

PMCID: PMC3819751.



25: Ramirez JO, Cabrera SA, Hidalgo H, Cabrera SG, Linnebank M, Bassetti CL,

Kallweit U. Is preeclampsia associated with restless legs syndrome? Sleep Med.

2013 Sep;14(9):894-6. doi: 10.1016/j.sleep.2013.03.013. Epub 2013 Jul 23. PubMed

PMID: 23891236.



26: Schippling S, Kempf C, Büchele F, Jelcic I, Bozinov O, Bont A, Linnebank M,

Sospedra M, Weller M, Budka H, Martin R. JC virus granule cell neuronopathy and

GCN-IRIS under natalizumab treatment. Ann Neurol. 2013 Oct;74(4):622-6. doi:

10.1002/ana.23973. Epub 2013 Sep 16. PubMed PMID: 23868420.



27: Gobbi C, Zecca C, Linnebank M, Müller S, You X, Meier R, Borter E, Traber M.

Swiss analysis of multiple sclerosis: a multicenter, non-interventional,

retrospective cohort study of disease-modifying therapies. Eur Neurol.

2013;70(1-2):35-41. doi: 10.1159/000346761. Epub 2013 May 14. PubMed PMID:




28: Kallweit U, Aritake K, Bassetti CL, Blumenthal S, Hayaishi O, Linnebank M,

Baumann CR, Urade Y. Elevated CSF histamine levels in multiple sclerosis

patients. Fluids Barriers CNS. 2013 May 9;10:19. doi: 10.1186/2045-8118-10-19.

eCollection 2013. PubMed PMID: 23659456; PubMed Central PMCID: PMC3656773.



29: Preiningerova JL, Baumhackl U, Csepany T, Czaplinski A, Deisenhammer F,

Derfuss T, Fabjan TH, Fazekas F, Fuchs S, Havrdova E, Ledinek AH, Illes Z, Jazbec

SS, Klimova E, Komoly S, Kurca E, Linnebank M, Lisy L, Mares J, Prochazkova L,

Csilla R, Szilasiova J, Stourac P, Talab R, Turcani P, Vachova M, Vecsei L,

Vodusek D, Zapletalova O, Berger T. Recommendations for the use of

prolonged-release fampridine in patients with multiple sclerosis (MS). CNS

Neurosci Ther. 2013 May;19(5):302-6. doi: 10.1111/cns.12101. PubMed PMID:




30: Semmler A, Prost JC, Smulders Y, Smith D, Blom H, Bigler L, Linnebank M.

Methylation metabolism in sepsis and systemic inflammatory response syndrome.

Scand J Clin Lab Invest. 2013 Aug;73(5):368-72. doi:

10.3109/00365513.2013.785587. Epub 2013 Apr 8. PubMed PMID: 23566119.



31: Semmler A, Moskau-Hartmann S, Stoffel-Wagner B, Elger C, Linnebank M.

Homocysteine plasma levels in patients treated with antiepileptic drugs depend on

folate and vitamin B12 serum levels, but not on genetic variants of homocysteine

metabolism. Clin Chem Lab Med. 2013 Mar 1;51(3):665-9. doi:

10.1515/cclm-2012-0580. PubMed PMID: 23382314.



32: Semmler A, Garbe S, Moskau S, Frisch C, Eter N, Schlegel U, Linnebank M. An

efficient method for fractionated whole rodent brain radiation. Neurol Res. 2013

May;35(4):355-9. doi: 10.1179/1743132812Y.0000000143. Epub 2013 Jan 10. PubMed

PMID: 23336750.



33: Kuebler U, Linnebank M, Semmler A, Stoffel-Wagner B, La Marca R, Ehlert U,

Wirtz PH. Plasma homocysteine levels increase following stress in older but not

younger men. Psychoneuroendocrinology. 2013 Aug;38(8):1381-7. doi:

10.1016/j.psyneuen.2012.12.003. Epub 2013 Jan 9. PubMed PMID: 23312061.



34: Schaub C, Uebachs M, Beck H, Linnebank M. Chronic homocysteine exposure

causes changes in the intrinsic electrophysiological properties of cultured

hippocampal neurons. Exp Brain Res. 2013 Apr;225(4):527-34. doi:

10.1007/s00221-012-3392-1. Epub 2013 Jan 10. PubMed PMID: 23307157.



35: Linnebank M, Moskau S, Semmler A, Hoefgen B, Bopp G, Kallweit U, Maier W,

Schütz CG, Wüllner U. A possible genetic link between MTHFR genotype and smoking

behavior. PLoS One. 2012;7(12):e53322. doi: 10.1371/journal.pone.0053322. Epub

2012 Dec 28. PubMed PMID: 23285280; PubMed Central PMCID: PMC3532068.



36: Farkas M, Keskitalo S, Smith DE, Bain N, Semmler A, Ineichen B, Smulders Y,

Blom H, Kulic L, Linnebank M. Hyperhomocysteinemia in Alzheimer's disease: the

hen and the egg? J Alzheimers Dis. 2013;33(4):1097-104. doi:

10.3233/JAD-2012-121378. PubMed PMID: 23099812.



37: Linnebank M, Moskau S, Kowoll A, Semmler A, Bangard C, Vogt-Schaden M, Egerer

G, Schackert G, Reichmann H, Schmidt-Wolf IG, Pels H, Schlegel U. Association of

transcobalamin c. 776C>G with overall survival in patients with primary central

nervous system lymphoma. Br J Cancer. 2012 Nov 20;107(11):1840-3. doi:

10.1038/bjc.2012.476. Epub 2012 Oct 25. PubMed PMID: 23099805; PubMed Central

PMCID: PMC3504945.



38: Harrer A, Tumani H, Niendorf S, Lauda F, Geis C, Weishaupt A, Kleinschnitz C,

Rauer S, Kuhle J, Stangel M, Weber F, Uhr M, Linnebank M, Wildemann B, Jarius S,

Guger M, Ayzenberg I, Chan A, Zettl U, Wiendl H, Pilz G, Hitzl W, Weber JR, Kraus

J. Cerebrospinal fluid parameters of B cell-related activity in patients with

active disease during natalizumab therapy. Mult Scler. 2013 Aug;19(9):1209-12.

doi: 10.1177/1352458512463483. Epub 2012 Oct 23. PubMed PMID: 23093485.



39: Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C,

Sweetser MT, Yang M, Sheikh SI, Dawson KT; DEFINE Study Investigators.

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.

N Engl J Med. 2012 Sep 20;367(12):1098-107. Erratum in: N Engl J Med. 2012 Dec

13;367(24):2362. PubMed PMID: 22992073.



40: Smith DE, Smulders YM, Blom HJ, Popp J, Jessen F, Semmler A, Farkas M,

Linnebank M. Determinants of the essential one-carbon metabolism metabolites,

homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in

cerebrospinal fluid. Clin Chem Lab Med. 2012 Mar 24;50(9):1641-7. doi:

10.1515/cclm-2012-0056. PubMed PMID: 22962226.



41: Schreglmann SR, Jelčić I, Taegtmeyer AB, Linnebank M, Weller M. Multifocal

CNS demyelination after octreotide treatment for metastatic meningioma. Clin

Neurol Neurosurg. 2013 Jun;115(6):817-9. doi: 10.1016/j.clineuro.2012.07.021.

Epub 2012 Aug 5. PubMed PMID: 22874886.



42: Radue EW, O'Connor P, Polman CH, Hohlfeld R, Calabresi P, Selmaj K,

Mueller-Lenke N, Agoropoulou C, Holdbrook F, de Vera A, Zhang-Auberson L, Francis

G, Burtin P, Kappos L; FTY720 Research Evaluating Effects of Daily Oral Therapy

in Multiple Sclerosis (FREEDOMS) Study Group. Impact of fingolimod therapy on

magnetic resonance imaging outcomes in patients with multiple sclerosis. Arch

Neurol. 2012 Oct;69(10):1259-69. PubMed PMID: 22751847.



43: Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F,

Böger RH, Popp J. Dimethylarginines, homocysteine metabolism, and cerebrospinal

fluid markers for Alzheimer's disease. J Alzheimers Dis. 2012;31(4):751-8. doi:

10.3233/JAD-2012-112138. PubMed PMID: 22710910.



44: Heese P, Linnebank M, Semmler A, Muschler MA, Heberlein A, Frieling H,

Stoffel-Wagner B, Kornhuber J, Banger M, Bleich S, Hillemacher T. Alterations of

homocysteine serum levels during alcohol withdrawal are influenced by folate and

riboflavin: results from the German Investigation on Neurobiology in Alcoholism

(GINA). Alcohol Alcohol. 2012 Sep-Oct;47(5):497-500. doi: 10.1093/alcalc/ags058.

Epub 2012 May 29. PubMed PMID: 22645037.



45: Devonshire V, Havrdova E, Radue EW, O'Connor P, Zhang-Auberson L, Agoropoulou

C, Häring DA, Francis G, Kappos L; FREEDOMS study group. Relapse and disability

outcomes in patients with multiple sclerosis treated with fingolimod: subgroup

analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.

Lancet Neurol. 2012 May;11(5):420-8. doi: 10.1016/S1474-4422(12)70056-X. Epub

2012 Apr 10. Erratum in: Lancet Neurol. 2012 Aug;11(8):658. PubMed PMID:




46: Linnebank M, Moskau S, Semmler A, Widman G, Weller M, Kallweit U, Elger CE.

Antiepileptic drugs and vitamin B6 plasma levels in adult patients. Epilepsy Res.

2012 Aug;101(1-2):182-4. doi: 10.1016/j.eplepsyres.2012.03.002. Epub 2012 Mar 30.

PubMed PMID: 22464176.



47: Grimaldi L, Barkhof F, Beelke M, Burton J, Holmoy T, Hupperts R, Killestein

J, Rieckmann P, Schluep M, Smolders J; SOLAR Study Group. A randomized trial of

high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology. 2012

Mar 13;78(11):841. doi: 10.1212/01.wnl.0000413180.13413.ce. PubMed PMID:




48: Petersen JA, Jung HH, Weller M, Linnebank M. Autoimmune myasthenia gravis

after sternal fracture. Case Rep Neurol. 2012 Jan;4(1):20-2. doi:

10.1159/000335992. Epub 2012 Jan 20. PubMed PMID: 22393321; PubMed Central PMCID:




49: Kallweit U, Jelcic I, Braun N, Fischer H, Zörner B, Schreiner B, Sokolov AA,

Martin R, Weller M, Linnebank M. Sustained efficacy of natalizumab in the

treatment of relapsing-remitting multiple sclerosis independent of disease

activity and disability at baseline: real-life data from a Swiss cohort. Clin

Neuropharmacol. 2012 Mar-Apr;35(2):77-80. doi: 10.1097/WNF.0b013e31824644e6.

PubMed PMID: 22318192.



50: Semmler A, Frisch C, Smith D, Blom H, Linnebank M. The ratio of

S-adenosylmethione and S-adenosyl-homocysteine is increased in the brains of

newborn rats in a model of valproic acid teratogenicity. Toxicology. 2012 Mar

11;293(1-3):132-3. doi: 10.1016/j.tox.2012.01.001. Epub 2012 Jan 11. PubMed PMID:




51: Semmler A, Moskau S, Lutz H, Meyer P, Linnebank M. Haplotype analysis of the

5,10-methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (E429A) polymorphism.

BMC Res Notes. 2011 Oct 24;4:439. doi: 10.1186/1756-0500-4-439. PubMed PMID:

22023786; PubMed Central PMCID: PMC3212962.



52: Bernhart-Just A, Kunkel S, Linnebank M, Staudacher D, Spirig R. [Competence

center for patients with multiple sclerosis: a future oriented health care

model]. Krankenpfl Soins Infirm. 2011;104(10):15-7. German. PubMed PMID:




53: Aly L, Yousef S, Schippling S, Jelcic I, Breiden P, Matschke J, Schulz R,

Bofill-Mas S, Jones L, Demina V, Linnebank M, Ogg G, Girones R, Weber T, Sospedra

M, Martin R. Central role of JC virus-specific CD4+ lymphocytes in progressive

multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome.

Brain. 2011 Sep;134(Pt 9):2687-702. doi: 10.1093/brain/awr206. PubMed PMID:




54: Conzett KB, Kolm I, Jelcic I, Kamarachev J, Dummer R, Braun R, French LE,

Linnebank M, Hofbauer GF. Melanoma occurring during treatment with fingolimod for

multiple sclerosis: a case report. Arch Dermatol. 2011 Aug;147(8):991-2. doi:

10.1001/archdermatol.2011.212. PubMed PMID: 21844470.



55: Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, Breteler

MM, Bautista LE, Sharma P, Whittaker JC, Smeeth L, Fowkes FG, Algra A, Shmeleva

V, Szolnoki Z, Roest M, Linnebank M, Zacho J, Nalls MA, Singleton AB, Ferrucci L,

Hardy J, Worrall BB, Rich SS, Matarin M, Norman PE, Flicker L, Almeida OP, van

Bockxmeer FM, Shimokata H, Khaw KT, Wareham NJ, Bobak M, Sterne JA, Smith GD,

Talmud PJ, van Duijn C, Humphries SE, Price JF, Ebrahim S, Lawlor DA, Hankey GJ,

Meschia JF, Sandhu MS, Hingorani AD, Casas JP. Effect modification by population

dietary folate on the association between MTHFR genotype, homocysteine, and

stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet.

2011 Aug 13;378(9791):584-94. doi: 10.1016/S0140-6736(11)60872-6. Epub 2011 Jul

29. PubMed PMID: 21803414; PubMed Central PMCID: PMC3156981.



56: Wittmann M, Dewald D, Urbach H, Gast AS, Linnebank M, Baumgarten G,

Knuefermann P, Hering R. Sinus venous thrombosis: a differential diagnosis of

postpartum headache. Arch Gynecol Obstet. 2012 Jan;285(1):93-7. doi:

10.1007/s00404-011-1964-0. Epub 2011 Jul 20. PubMed PMID: 21773786.



57: Patrij K, Reiser M, Wätzel L, Pels H, Kowoll A, Herrlinger U, Engert A,

Linnebank M, Schackert G, Vogt-Schaden M, Egerer G, Lamprecht M, Batchelor TT,

Schlegel U, Schmidt-Wolf IG; International Primary CNS Lymphoma Collaborative

Group (IPCG). Isolated central nervous system relapse of systemic lymphoma

(SCNSL): clinical features and outcome of a retrospective analysis. Ger Med Sci.

2011;9:Doc11. doi: 10.3205/000134. Epub 2011 May 2. PubMed PMID: 21698087; PubMed

Central PMCID: PMC3118693.



58: Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger

CE. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann

Neurol. 2011 Feb;69(2):352-9. doi: 10.1002/ana.22229. Epub 2011 Jan 19. PubMed

PMID: 21246600.



59: Kühnlein P, Jung H, Farkas M, Keskitalo S, Ineichen B, Jelcic I, Petersen J,

Semmler A, Weller M, Ludolph AC, Linnebank M. The thermolabile variant of

5,10-methylenetetrahydrofolate reductase is a possible risk factor for

amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Mar;12(2):136-9.

doi: 10.3109/17482968.2010.536985. Epub 2010 Dec 6. PubMed PMID: 21128869.



60: Semmler A, Farmand S, Moskau S, Stoffel-Wagner B, Linnebank M. The G allele

of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein

profile. Ann Nutr Metab. 2010;57(2):112-5. doi: 10.1159/000320418. Epub 2010 Oct

14. PubMed PMID: 20948192.



61: Semmler A, Moskau S, Grigull A, Farmand S, Klockgether T, Smulders Y, Blom H,

Zur B, Stoffel-Wagner B, Linnebank M. Plasma folate levels are associated with

the lipoprotein profile: a retrospective database analysis. Nutr J. 2010 Jul

28;9:31. doi: 10.1186/1475-2891-9-31. PubMed PMID: 20667074; PubMed Central

PMCID: PMC2916887.



62: Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L,

Cvetanovska G, Blom H, Stoffel-Wagner B, Kölsch H, Weller M, Jessen F.

S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with

Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657.

Epub 2010 Jun 3. PubMed PMID: 20523031.



63: Riederer F, Sándor PS, Linnebank M, Ettlin DA. Familial occipital and nervus

intermedius neuralgia in a Swiss family. J Headache Pain. 2010 Aug;11(4):335-8.

doi: 10.1007/s10194-010-0207-2. Epub 2010 Mar 28. PubMed PMID: 20349261; PubMed

Central PMCID: PMC3476342.



64: Tamagni C, Mondadori CR, Valko PO, Brugger P, Schuknecht B, Linnebank M.

Cerebellum and source memory. Eur Neurol. 2010;63(4):234-6. doi:

10.1159/000282277. Epub 2010 Mar 19. PubMed PMID: 20299799.



65: Kurzwelly D, Knop S, Guenther M, Loeffler J, Korfel A, Thiel E, Hebart H,

Simon M, Weller M, Linnebank M, Herrlinger U. Genetic variants of folate and

methionine metabolism and PCNSL incidence in a German patient population. J

Neurooncol. 2010 Nov;100(2):187-92. doi: 10.1007/s11060-010-0154-4. Epub 2010 Mar

17. PubMed PMID: 20237949.



66: Juergens A, Pels H, Rogowski S, Fliessbach K, Glasmacher A, Engert A, Reiser

M, Diehl V, Vogt-Schaden M, Egerer G, Schackert G, Reichmann H, Kroschinsky F,

Bode U, Herrlinger U, Linnebank M, Deckert M, Fimmers R, Schmidt-Wolf IG,

Schlegel U. Long-term survival with favorable cognitive outcome after

chemotherapy in primary central nervous system lymphoma. Ann Neurol. 2010

Feb;67(2):182-9. doi: 10.1002/ana.21824. PubMed PMID: 20225195.



67: Hofer S, Linnebank M, Weller M, Bahmanyar S, Montgomery SM, Hillert J, Ekbom

A, Olsson T. Cancer risk among patients with multiple sclerosis and their

parents. Neurology. 2010 Feb 16;74(7):614-5; author reply 615. doi:

10.1212/WNL.0b013e3181c777b7. PubMed PMID: 20157167.



68: Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K,

Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P; FREEDOMS Study Group. A

placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N

Engl J Med. 2010 Feb 4;362(5):387-401. doi: 10.1056/NEJMoa0909494. Epub 2010 Jan

20. PubMed PMID: 20089952.



69: Semmler A, Moskau S, Stoffel-Wagner B, Weller M, Linnebank M. The effect of

MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking.

Clin Invest Med. 2009 Dec 1;32(6):E310. PubMed PMID: 20003837.



70: Moskau S, Semmler A, Stoffel-Wagner B, Linnebank M. Plasma homocysteine

levels after acute stroke and in the convalescent phase. Can J Neurol Sci. 2009

Nov;36(6):789-90. PubMed PMID: 19960764.



71: Klotz L, Farkas M, Bain N, Keskitalo S, Semmler A, Ineichen B, Jelcic J,

Klockgether T, Kölsch H, Weller M, Linnebank M. The variant

methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with

multiple sclerosis in a German case-control study. Neurosci Lett. 2010 Jan

14;468(3):183-5. doi: 10.1016/j.neulet.2009.10.057. Epub 2009 Oct 23. PubMed

PMID: 19854238.



72: Ackermann R, Semmler A, Maurer GD, Hattingen E, Fornoff F, Steinbach JP,

Linnebank M. Methotrexate-induced myelopathy responsive to substitution of

multiple folate metabolites. J Neurooncol. 2010 May;97(3):425-7. doi:

10.1007/s11060-009-0028-9. Epub 2009 Oct 11. PubMed PMID: 19821069.



73: Stanger O, Fowler B, Piertzik K, Huemer M, Haschke-Becher E, Semmler A,

Lorenzl S, Linnebank M. Homocysteine, folate and vitamin B12 in neuropsychiatric

diseases: review and treatment recommendations. Expert Rev Neurother. 2009

Sep;9(9):1393-412. doi: 10.1586/ern.09.75. Review. PubMed PMID: 19769453.



74: Popp J, Lewczuk P, Linnebank M, Cvetanovska G, Smulders Y, Kölsch H, Frommann

I, Kornhuber J, Maier W, Jessen F. Homocysteine metabolism and cerebrospinal

fluid markers for Alzheimer's disease. J Alzheimers Dis. 2009;18(4):819-28. doi:

10.3233/JAD-2009-1187. PubMed PMID: 19661622.



75: Moskau S, Smolka K, Semmler A, Schweichel D, Harbrecht U, Müller J, Pohl C,

Klockgether T, Linnebank M. Common genetic coagulation variants are not

associated with ischemic stroke in a case-control study. Neurol Res. 2010

Jun;32(5):519-22. doi: 10.1179/016164109X12464612122533. Epub 2009 Aug 5. PubMed

PMID: 19660184.



76: Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M,

Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A,

Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom

A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong

G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy

M, Houlston RS. Genome-wide association study identifies five susceptibility loci

for glioma. Nat Genet. 2009 Aug;41(8):899-904. doi: 10.1038/ng.407. Epub 2009 Jul

5. PubMed PMID: 19578367; PubMed Central PMCID: PMC4501476.



77: Lenz B, Soehngen C, Linnebank M, Heberlein A, Frieling H, Kornhuber J,

Hillemacher T, Bleich S. Genetic polymorphisms relevant for one-carbon metabolism

show no effect on homocysteine plasma levels and DNA methylation in alcoholism.

Psychiatr Genet. 2009 Aug;19(4):215-6. doi: 10.1097/YPG.0b013e32832cec44. PubMed

PMID: 19461557.



78: Häberle J, Pauli S, Berning C, Koch HG, Linnebank M. TC II deficiency:

avoidance of false-negative molecular genetics by RNA-based investigations. J Hum

Genet. 2009 Jun;54(6):331-4. doi: 10.1038/jhg.2009.34. Epub 2009 Apr 17. PubMed

PMID: 19373259.



79: Semmler A, Bao X, Cao G, Köhler W, Weller M, Aubourg P, Linnebank M. Genetic

variants of methionine metabolism and X-ALD phenotype generation: results of a

new study sample. J Neurol. 2009 Aug;256(8):1277-80. doi:

10.1007/s00415-009-5114-6. Epub 2009 Apr 8. PubMed PMID: 19353223.



80: Rakovic A, Stiller B, Djarmati A, Flaquer A, Freudenberg J, Toliat MR,

Linnebank M, Kostic V, Lohmann K, Paus S, Nürnberg P, Kubisch C, Klein C, Wüllner

U, Ramirez A. Genetic association study of the P-type ATPase ATP13A2 in

late-onset Parkinson's disease. Mov Disord. 2009 Feb 15;24(3):429-33. doi:

10.1002/mds.22399. PubMed PMID: 19097176.



81: Happold C, Roth P, Wick W, Steinbach JP, Linnebank M, Weller M, Eisele G.

ACNU-based chemotherapy for recurrent glioma in the temozolomide era. J

Neurooncol. 2009 Mar;92(1):45-8. doi: 10.1007/s11060-008-9728-9. Epub 2008 Nov 6.

PubMed PMID: 18987781.



82: Pels H, Juergens A, Glasmacher A, Schulz H, Engert A, Linnebank M, Schackert

G, Reichmann H, Kroschinsky F, Vogt-Schaden M, Egerer G, Bode U, Schaller C,

Lamprecht M, Hau P, Deckert M, Fimmers R, Bangard C, Schmidt-Wolf IG, Schlegel U.

Early relapses in primary CNS lymphoma after response to polychemotherapy without

intraventricular treatment: results of a phase II study. J Neurooncol. 2009

Feb;91(3):299-305. doi: 10.1007/s11060-008-9712-4. Epub 2008 Oct 18. PubMed PMID:




83: Semmler A, Smulders Y, Struys E, Smith D, Moskau S, Blom H, Linnebank M.

Methionine metabolism in an animal model of sepsis. Clin Chem Lab Med.

2008;46(10):1398-402. doi: 10.1515/CCLM.2008.277. PubMed PMID: 18844494.



84: Linnebank M, Moskau S, Jürgens A, Simon M, Semmler A, Orlopp K, Glasmacher A,

Bangard C, Vogt-Schaden M, Urbach H, Schmidt-Wolf IG, Pels H, Schlegel U.

Association of genetic variants of methionine metabolism with

methotrexate-induced CNS white matter changes in patients with primary CNS

lymphoma. Neuro Oncol. 2009 Feb;11(1):2-8. doi: 10.1215/15228517-2008-082. Epub

2008 Sep 19. PubMed PMID: 18806228; PubMed Central PMCID: PMC2718955.



85: Semmler A, Linnebank M, Krex D, Götz A, Moskau S, Ziegler A, Simon M.

Polymorphisms of homocysteine metabolism are associated with intracranial

aneurysms. Cerebrovasc Dis. 2008;26(4):425-9. doi: 10.1159/000155638. Epub 2008

Sep 18. PubMed PMID: 18799873.



86: Semmler A, Köhler W, Jung HH, Weller M, Linnebank M. Therapy of X-linked

adrenoleukodystrophy. Expert Rev Neurother. 2008 Sep;8(9):1367-79. doi:

10.1586/14737175.8.9.1367. Review. PubMed PMID: 18759549.



87: Kurzwelly D, Müller CA, Korfel A, Thiel E, Linnebank M, Weller M, Herrlinger

U. Primary CNS lymphoma and HLA class I and II alleles in a German cohort of

immunocompetent patients. J Neurooncol. 2008 Oct;90(1):53-5. doi:

10.1007/s11060-008-9630-5. Epub 2008 Jun 28. PubMed PMID: 18587537.



88: Linnebank M, Semmler A, Moskau S, Smulders Y, Blom H, Simon M. The

methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences

overall survival of patients with glioblastoma multiforme. Neuro Oncol. 2008

Aug;10(4):548-52. doi: 10.1215/15228517-2008-020. Epub 2008 May 22. PubMed PMID:

18497326; PubMed Central PMCID: PMC2666227.



89: Semmler A, Simon M, Moskau S, Linnebank M. Polymorphisms of methionine

metabolism and susceptibility to meningioma formation: laboratory investigation.

J Neurosurg. 2008 May;108(5):999-1004. doi: 10.3171/JNS/2008/108/5/0999. PubMed

PMID: 18447718.



90: Hillemacher T, Frieling H, Moskau S, Muschler MA, Semmler A, Kornhuber J,

Klockgether T, Bleich S, Linnebank M. Global DNA methylation is influenced by

smoking behaviour. Eur Neuropsychopharmacol. 2008 Apr;18(4):295-8. doi:

10.1016/j.euroneuro.2007.12.005. Epub 2008 Jan 31. PubMed PMID: 18242065.



91: Lorenzl S, Linnebank M, Stanger O. B vitamins and cerebral ischemia. Dtsch

Arztebl Int. 2008 Feb;105(7):128-9; author reply 129. doi:

10.3238/arztebl.2008.0128c. Epub 2008 Feb 15. PubMed PMID: 19633766; PubMed

Central PMCID: PMC2696725.



92: Becker A, Vezmar S, Linnebank M, Pels H, Bode U, Schlegel U, Jaehde U. Marked

elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal

fluid of lymphoma patients receiving intensive treatment with methotrexate. Int J

Clin Pharmacol Ther. 2007 Sep;45(9):504-15. PubMed PMID: 17907593.



93: Linnebank M, Malessa S, Moskau S, Semmler A, Pels H, Klockgether T, Schlegel

U. Acute methotrexate-induced encephalopathy--causal relation to homozygous

allelic state for MTR c.2756A>G (D919G)? J Chemother. 2007 Aug;19(4):455-7.

PubMed PMID: 17855192.



94: Semmler A, Klein A, Moskau S, Linnebank M. Transient global amnesia-like

episode in a patient with severe hyperhomocysteinemia. Eur J Neurol. 2007

Sep;14(9):e5-6. PubMed PMID: 17718682.



95: Semmler A, Urbach H, Klockgether T, Linnebank M. Progressive multifocal

leukoencephalopathy with selective involvement of the pyramidal tracts.

Neurology. 2007 Mar 13;68(11):871. PubMed PMID: 17353479.



96: Moskau S, Farmand S, Semmler A, Wüllner U, Pohl C, Klockgether T, Linnebank

M. The methionine synthase polymorphism c.2756A>G (D919G) influences diastolic

blood pressure. J Hum Hypertens. 2007 May;21(5):418-20. Epub 2007 Feb 8. PubMed

PMID: 17287836.



97: Volk A, Karbasiyan M, Semmler A, Todt U, Urbach H, Klockgether T, Linnebank

M. Adult index patient with Currarino syndrome due to a novel HLXB9 mutation,

c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and

lumbodynia. Birth Defects Res A Clin Mol Teratol. 2007 Mar;79(3):249-51. PubMed

PMID: 17183586.



98: Semmler A, Simon M, Moskau S, Linnebank M. The methionine synthase

polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme. Cancer

Epidemiol Biomarkers Prev. 2006 Nov;15(11):2314-6. PubMed PMID: 17119065.



99: Vyletal P, Sokolová J, Cooper DN, Kraus JP, Krawczak M, Pepe G, Rickards O,

Koch HG, Linnebank M, Kluijtmans LA, Blom HJ, Boers GH, Gaustadnes M, Skovby F,

Wilcken B, Wilcken DE, Andria G, Sebastio G, Naughten ER, Yap S, Ohura T,

Pronicka E, Laszlo A, Kozich V. Diversity of cystathionine beta-synthase

haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible

role for gene conversion. Hum Mutat. 2007 Mar;28(3):255-64. PubMed PMID:

17072863; PubMed Central PMCID: PMC2630376.



100: Linnebank M, Moskau S, Farmand S, Fliessbach K, Kölsch H, Bös M, Grothe C,

Becker D, Harbrecht U, Pohl C, Wüllner U, Klockgether T. Homocysteine and carotid

intima-media thickness in a german population: lack of clinical relevance.

Stroke. 2006 Nov;37(11):2840-2. Epub 2006 Sep 28. PubMed PMID: 17008631.



101: Semmler A, Stein RW, Caplan L, Danilov SM, Klockgether T, Linnebank M.

Hereditary hyper-ACE-emia due to the Pro1199Leu mutation of somatic ACE as a

potential pitfall in diagnosis: a first family outside Europe. Clin Chem Lab Med.

2006;44(9):1088-9. PubMed PMID: 16958600.



102: Linnebank M, Semmler A, Kleijer WJ, van der Sterre ML, Gärtner J, Fliessbach

K, Sokolowski P, Köhler W, Schlegel U, Klockgether T, Wanders RJ, Schmidt S,

Wüllner U, Kemp S. The cystathionine beta-synthase variant c.844_845ins68

protects against CNS demyelination in X-linked adrenoleukodystrophy. Hum Mutat.

2006 Oct;27(10):1063-4. PubMed PMID: 16941496.



103: Wellmer J, Sturm KU, Herrmann W, Hoever J, Klockgether T, Linnebank M. [Oral

treatment of vitamin B12 deficiency in subacute combined degeneration].

Nervenarzt. 2006 Oct;77(10):1228-31. German. PubMed PMID: 16897048.



104: Linnebank M, Lutz H, Jarre E, Vielhaber S, Noelker C, Struys E, Jakobs C,

Klockgether T, Evert BO, Kunz WS, Wüllner U. Binding of copper is a mechanism of

homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons,

PC12 and SHSY-5Y cells. Neurobiol Dis. 2006 Sep;23(3):725-30. Epub 2006 Jul 28.

PubMed PMID: 16876425.



105: Linnebank M, Kemp S, Wanders RJ, Kleijer WJ, van der Sterre ML, Gärtner J,

Fliessbach K, Semmler A, Sokolowski P, Köhler W, Schlegel U, Schmidt S,

Klockgether T, Wüllner U. Methionine metabolism and phenotypic variability in

X-linked adrenoleukodystrophy. Neurology. 2006 Feb 14;66(3):442-3. PubMed PMID:




106: Linnebank M, Lagler F, Muntau AC, Röschinger W, Olgemöller B, Fowler B, Koch

HG. Methionine adenosyltransferase (MAT) I/III deficiency with concurrent

hyperhomocysteinaemia: two novel cases. J Inherit Metab Dis. 2005;28(6):1167-8.

PubMed PMID: 16435220.



107: Wüllner U, Kölsch H, Linnebank M. Methylenetetrahydrofolate reductase in

Parkinson's disease. Ann Neurol. 2005 Dec;58(6):972-3. PubMed PMID: 16315277.



108: Palmedo H, Urbach H, Bender H, Schlegel U, Schmidt-Wolf IG, Matthies A,

Linnebank M, Joe A, Bucerius J, Biersack HJ, Pels H. FDG-PET in immunocompetent

patients with primary central nervous system lymphoma: correlation with MRI and

clinical follow-up. Eur J Nucl Med Mol Imaging. 2006 Feb;33(2):164-8. Epub 2005

Oct 12. PubMed PMID: 16220304.



109: Linnebank M, Fliessbach K, Kolsch H, Rietschel M, Wullner U. The methionine

synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for

disease-free longevity. Int J Mol Med. 2005 Oct;16(4):759-61. PubMed PMID:




110: Linnebank M, Montenarh M, Kölsch H, Linnebank A, Schnez K, Schweichel D,

Pohl C, Urbach H, Heun R, Harbrecht U, Klockgether T, Wüllner U. Common genetic

variants of homocysteine metabolism in ischemic stroke: a case-control study. Eur

J Neurol. 2005 Aug;12(8):614-8. PubMed PMID: 16053469.



111: Fliessbach K, Helmstaedter C, Urbach H, Althaus A, Pels H, Linnebank M,

Juergens A, Glasmacher A, Schmidt-Wolf IG, Klockgether T, Schlegel U.

Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a

prospective study. Neurology. 2005 Apr 12;64(7):1184-8. PubMed PMID: 15824344.



112: Linnebank M, Pels H, Kleczar N, Farmand S, Fliessbach K, Urbach H, Orlopp K,

Klockgether T, Schmidt-Wolf IG, Schlegel U. MTX-induced white matter changes are

associated with polymorphisms of methionine metabolism. Neurology. 2005 Mar

8;64(5):912-3. PubMed PMID: 15753437.



113: Kölsch H, Linnebank M, Lütjohann D, Jessen F, Wüllner U, Harbrecht U, Thelen

KM, Kreis M, Hentschel F, Schulz A, von Bergmann K, Maier W, Heun R.

Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and

stroke. Neurology. 2004 Dec 28;63(12):2255-60. PubMed PMID: 15623683.



114: Linnebank M, Linnebank A, Jeub M, Klockgether T, Wüllner U, Kölsch H, Heun

R, Koch HG, Suormala T, Fowler B. Lack of genetic dispositions to

hyperhomocysteinemia in Alzheimer disease. Am J Med Genet A. 2004 Nov

15;131(1):101-2. PubMed PMID: 15389705.



115: Linnebank M, Janosik M, Kozich V, Pronicka E, Kubalska J, Sokolova J,

Linnebank A, Schmidt E, Leyendecker C, Klockgether T, Kraus JP, Koch HG. The

cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin

B6 nonresponsiveness and a common ancestral haplotype. Hum Mutat. 2004

Oct;24(4):352-3. PubMed PMID: 15365998.



116: Orendáè M, Pronicka E, Kubalska J, Janosik M, Sokolová J, Linnebank M, Koch

HG, Kozich V. Identification and functional analysis of two novel mutations in

the CBS gene in Polish patients with homocystinuria. Hum Mutat. 2004

Jun;23(6):631. PubMed PMID: 15146473.



117: Linnebank M, Schmidt S, Kölsch H, Linnebank A, Heun R, Schmidt-Wolf IG,

Glasmacher A, Fliessbach K, Klockgether T, Schlegel U, Pels H. The methionine

synthase polymorphism D919G alters susceptibility to primary central nervous

system lymphoma. Br J Cancer. 2004 May 17;90(10):1969-71. PubMed PMID: 15138479;

PubMed Central PMCID: PMC2409477.



118: Gehrmann J, Sohlbach K, Linnebank M, Böhles HJ, Buderus S, Kehl HG, Vogt J,

Harms E, Marquardt T. Cardiomyopathy in congenital disorders of glycosylation.

Cardiol Young. 2003 Aug;13(4):345-51. Review. PubMed PMID: 14694955.



119: Linnebank M, Kesper K, Jeub M, Urbach H, Wüllner U, Klockgether T, Schmidt

S. Hereditary elevation of angiotensin converting enzyme suggesting

neurosarcoidosis. Neurology. 2003 Dec 23;61(12):1819-20. PubMed PMID: 14694062.



120: Linnebank M, Junker R, Nabavi DG, Linnebank A, Koch HG. Isolated thrombosis

due to the cystathionine beta-synthase mutation c.833T>C (1278T). J Inherit Metab

Dis. 2003;26(5):509-11. PubMed PMID: 14518832.



121: Linnebank M, Homberger A, Nowak-Göttl U, Koch HG. A common haplotype for the

677T thermolabile variant of the 5,10-methylenetetrahydrofolate reductase gene in

thrombophilic patients and controls. Hum Mutat. 2002 Dec;20(6):478. PubMed PMID:




122: Kleijer WJ, Garritsen VH, Linnebank M, Mooyer P, Huijmans JG, Mustonen A,

Simola KO, Arslan-Kirchner M, Battini R, Briones P, Cardo E, Mandel H, Tschiedel

E, Wanders RJ, Koch HG. Clinical, enzymatic, and molecular genetic

characterization of a biochemical variant type of argininosuccinic aciduria:

prenatal and postnatal diagnosis in five unrelated families. J Inherit Metab Dis.

2002 Sep;25(5):399-410. PubMed PMID: 12408190.



123: Linnebank M, Tschiedel E, Häberle J, Linnebank A, Willenbring H, Kleijer WJ,

Koch HG. Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27

patients and a completed structure of the human ASL gene. Hum Genet. 2002

Oct;111(4-5):350-9. Epub 2002 Aug 14. PubMed PMID: 12384776.



124: Häberle J, Pauli S, Linnebank M, Kleijer WJ, Bakker HD, Wanders RJ, Harms E,

Koch HG. Structure of the human argininosuccinate synthetase gene and an improved

system for molecular diagnostics in patients with classical and mild

citrullinemia. Hum Genet. 2002 Apr;110(4):327-33. Epub 2002 Mar 1. PubMed PMID:




125: Linnebank M, Homberger A, Junker R, Nowak-Goettl U, Harms E, Koch HG. High

prevalence of the I278T mutation of the human cystathionine beta-synthase

detected by a novel screening application. Thromb Haemost. 2001 Jun;85(6):986-8.

PubMed PMID: 11434706.



126: Rapp B, Häberle J, Linnebank M, Wermuth B, Marquardt T, Harms E, Koch HG.

Genetic analysis of carbamoylphosphate synthetase I and ornithine

transcarbamylase deficiency using fibroblasts. Eur J Pediatr. 2001

May;160(5):283-7. PubMed PMID: 11388595.



127: Linnebank M, Homberger A, Kraus JP, Harms E, Kozich V, Koch HG. Haplotyping

of wild type and I278T alleles of the human cystathionine beta-synthase gene

based on a cluster of novel SNPs in IVS12. Hum Mutat. 2001 Apr;17(4):350-1.

PubMed PMID: 11295835.



128: Homberger A, Linnebank M, Winter C, Willenbring H, Marquardt T, Harms E,

Koch HG. Genomic structure and transcript variants of the human

methylenetetrahydrofolate reductase gene. Eur J Hum Genet. 2000 Sep;8(9):725-9.

PubMed PMID: 10980581.



129: Linnebank M, Homberger A, Rapp B, Winter C, Marquardt T, Harms E, Koch HG.

Two novel mutations (E86A, R113W) in argininosuccinate lyase deficiency and

evidence for highly variable splicing of the human argininosuccinate lyase gene.

J Inherit Metab Dis. 2000 Jun;23(4):308-12. PubMed PMID: 10896281.



130: Linnebank M, Homberger A, Nowak-Göttl U, Marquardt T, Harms E, Koch HG.

Linkage disequilibrium of the common mutations 677C > T and 1298A > C of the

human methylenetetrahydrofolate reductase gene as proven by the novel

polymorphisms 129C > T, 1068C > T. Eur J Pediatr. 2000 Jun;159(6):472-3. PubMed

PMID: 10867857.



131: Linnebank M, Homberger A, Koch HG, Bova I, Sylantiev C, Bornstein NM,

Chapman J, Korczyn AD. Frequent polymorphism of the human

methylenetetrahydrofolate reductase. Stroke. 2000 Apr;31(4):990. PubMed PMID:




132: Koch HG, Nabel P, Junker R, Auberger K, Schobess R, Homberger A, Linnebank M, Nowak-Göttl U. The 677T genotype of the common MTHFR thermolabile variant and

fasting homocysteine in childhood venous thrombosis. Eur J Pediatr. 1999 Dec;158

Suppl 3:S113-6. PubMed PMID: 10650848.



133: Körner C, Linnebank M, Koch HG, Harms E, von Figura K, Marquardt T.

Decreased availability of GDP-L-fucose in a patient with LAD II with normal

GDP-D-mannose dehydratase and FX protein activities. J Leukoc Biol. 1999

Jul;66(1):95-8. PubMed PMID: 10410995.


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